Lung W/D weight ratios in BALB/c mice receiving the indicated transfusions of antibody and/or CRP. (A) Injection of isotype mouse IgG2a antibody or 34-1-2s alone did not result in lung damage, similar to untreated naïve mice. (B) Injection of CRP together with 34-1-2s results in increased lung W/D weight ratios compared with CRP injection with isotype IgG2a or CRP alone. Ninety minutes after antibody and/or CRP injections, mice were euthanized and lungs were harvested. Each dot represents 1 mouse, and error bars represent standard deviation (SD). Only comparisons of significance are shown and determined by 1-way analysis of variance (ANOVA) with Tukey’s post hoc. NS, nonsignificant. ***P < .001.