T-cell and B-cell kinetics during cycle 1 (day 1 to 29) and cycle 2 (day 43 to 71) of blinatumomab treatment. (A) CD3⁺ T-cell expansion. (B) CD3⁺ T_EM-cell expansion. (C) CD19⁺ B-cell depletion. Patients were grouped according to MRD response and duration of OS (<30 vs ≥30 months). Data shown are median cell values (interquartile range) with numbers of evaluable data points per patient subgroup at each time point given below. For clarity, initial T-cell redistribution during the first treatment week of cycles 1 and 2 is not shown.