Implementing BAP. BAP: regular, ongoing infusions of rFVIIa or aPCC to reduce bleeding incidence. BAP dosing: rFVIIa, 90 µg/kg per day, or aPCC, 85 U/kg thrice weekly (if breakthrough bleeds continue, increase to 85 U/kg every other day). BAP duration: continue indefinitely and halt only when treatment is ineffective in reducing bleeding, problems develop with an indwelling line, or adverse drug reactions occur.