Manhattan plot of results from meta-analysis. Inverse of log P value for SNP associations with osteonecrosis risk from meta-analysis of COG AALL0232 (n = 2285), SJ Total XV (n = 361), and Vanderbilt BioVU (n = 309), adjusting for age, gender, treatment, and ancestry group in COG AALL0232 and SJ, and adjusting for age, gender, and ancestry groups in Vanderbilt BioVU. SNPs near GRIN3A and within GRIK1 had the strongest association.