Effect size for rs10989692 and rs2154490 genotypes by cohort. Effect sizes are computed as the HR for COG AALL0232 based on time-dependent analysis, and OR for SJ Total XV and Vanderbilt BioVU based on time-independent analyses. Effect sizes for rs10989692 and rs2154490 are shown after adjusting for age, gender, treatment arm, and ancestry in COG and SJ, and after adjusting for age, gender, and ancestry in Vanderbilt BioVU. Asterisk (*) denotes effect size.