Cumulative incidence of osteonecrosis by rs10989692 genotype in COG AALL0232. The cumulative incidence of osteonecrosis was higher in those carrying the A allele at rs10989692 (5′ of GRIN3A) in COG AALL0232 (A) in all ancestry groups combined, adjusting for ancestry (n = 2285), and (B) among whites only (n = 1268).