Hypoxia/reoxygenation stress (H/R) downregulates osteoblastogenesis, induces osteoclastogenesis, upregulates peroxiredoxin-2, anti-oxidant system. Zoledronic acid plays a preventing role in H/R-induced molecular bone expression. Runx2, Sparc, RankL, and Rank (A), IL-6 (B), and Prx2 (C) mRNA fold change in healthy (AA) and sickle cell (SS) mice exposed to H/R stress without and with Zol treatment before (pre-Zol). The fold change for each gene expression was obtained by using 2 different housekeeping genes (Gapdh and β-Actin). Data are shown as mean ± SD (n = 6); *P < .05; **P < .005.