A new slan-based nomenclature for circulating CD16⁺ monocytes. slan identifies subsets of peripheral blood CD16⁺ monocytes that are differentially altered in frequency during sarcoidosis (increased frequency of slan-negative CD16⁺ monocytes in males) vs HDLS (reduced frequency of slan-positive CD16⁺ monocytes). This new slan-based classification offers a better understanding of monocyte development during homeostasis and disease pathogenesis.