Time course of Erfe and Gypa mRNA expression in the marrow and the spleen of WT and Th3/+ mice.Erfe (A) and glycophorin A (Gypa) (B) mRNA expression in the marrow and the spleen was compared between WT and Th3/+ mice at 3, 6, and 12 weeks of age. Erfe mRNA level was significantly elevated at all ages in Th3/+ mice compared with WT mice, and its expression was already maximal in the marrow and spleen of 3-week-old animals. Gypa expression was unchanged in the marrow but significantly elevated in the spleen of Th3/+ mice compared with WT mice. Data shown are means ± SEM and were compared for each point between WT and Th3/+ mice (n = 9-24 per group) by 2-tailed Student t-test. ***P < .001, *P < .05.