The in vivo function of ERRFI1, SPRED1, and FZD7 in AE9a-mediated leukemogenesis. (A) Kaplan-Meier curves are shown for 3 groups of transplanted mice: MSCV-PIG (Control, n = 5), MSCV-PIG-Errfi1 (Errfi1, n = 4), and MSCV-PIG-Spred1 (Spred1, n = 5). The leukemic BM cells collected from tertiary miR-126+AE9a BMT recipients were used as the donor cells. The P values were calculated by log-rank test. (B) Kaplan-Meier curves are shown for 2 groups of transplanted mice: MSCV-PIG (Control, n = 5) and MSCV-PIG-Fzd7 (Fzd7, n = 6). The leukemia BM cells collected from tertiary AE9a BMT recipients were used as the donor cells. The P value was calculated by log-rank test. (C) Schematic model of target genes and signaling pathways activated in AE9a+miR-126 cells (left) and miR-126KO+AE9a cells (right).