Clustering diagram of gene mutations distribution. Rows correspond to cytogenetics (11q or 17p deletion) or sequenced gene and columns represent individual patients. Patients are clustered according to (i) number of genes mutations (0 in cluster 1, 1 in cluster 2, ≥2 in clusters 3 and 4) and (ii) recurrence of combinations (≥5% of cases in cluster 3 or <5% of cases in cluster 4). Color coding is based on the marker status (white, no 11q deletion, no 17p deletion or no gene mutation; black, 17p deletion or 11q deletion; red, gene mutated; gray, missing data).