Incidence of gene mutations and correlation with genomic features. (A) Number and type of mutation (left) and number of affected patients (right) of each sequenced gene. (B) Circos diagrams illustrating pairwise co-occurrence of gene mutations with cytogenetics (left, n = 110 patients) and IGHV status (right, n = 96 patients). The length of the arc depicts the frequency of the marker and the width of the ribbon corresponds to the proportion of co-occurrence with the second marker. Co-occurrences among genes mutations or among cytogenetics are not shown. 17p, 17p deletion; 11q, 11q deletion; IGHV M, mutated IGHV; IGHV UM, unmutated IGHV; *P < .05.