DC-SIGN treatment induces MYC expression in FL cells. Comparison of the ability of DC-SIGN to upregulate MYC in primary FL cells in relation to anti-Ig stimulation. (A) Western blotting was used to measure MYC protein expression in FL cells treated with isotype control, DC-SIGN, or anti-Ig beads over time (2 representative samples shown). (B) Fold-change analysis of band densitometry was used to compare MYC expression induced by each treatment of 11 FL samples tested (Student t test). (C) Western blotting was used to examine MYC expression in normal B cells treated with either DC-SIGN or anti-IgM beads over time.