![The images referred to the same case at (A) disease onset, (B) first relapse, and (C) second relapse. The tumor consists of cells characterized by a clear rim of cytoplasm and TFH phenotype as defined by the expression of PD1, CXCL13, BCL6, CD10, and ICOS (not shown); in panel A, it has a “follicular” growth pattern (hematoxylin and eosin, ×20), and in panel B, it has the typical “angioimmunoblastic” appearance (please note the hyperplastic HEV and the inflammatory component [hematoxylin and eosin, ×400]). In panel C, the “angioimmunoblastic” characteristics are lost and neoplastic cells acquire at least in part a more blastic appearance (hematoxylin and eosin, ×400).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/15/10.1182_blood-2015-08-665075/4/1733f1.jpeg?Expires=1724253261&Signature=hKCHjhEfI37H4Eg~EPzyN2GidsVqFvU4qJisVJmHHJWlpB0kkgka4MZkB0weHZTJ9hhqapCX69vBam3mTFcht7a1flGkWMxz5qBpewYbCy1A8wFA82u0x4aJr4M9uN7NRGrVuUHhVt3ROc3BpYrxwVoBnsFfVc1DKxgIsvJRK0bcvCW~VDxTZX9wZ2-rEX5XFkAKLJqswECwexHTL4XtXxTHfG0bV0wUxk6DXzK~t86FQqe0c7h5m8MEnKBqtUB4vkBSy1iDhaIz2EYYIpjzYeA7z54Pty0eKkaJwq598p6oOlQ4ufB4c892eiEoHw~9bg5GfjrAw2Aocc31EGsiaQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The images referred to the same case at (A) disease onset, (B) first relapse, and (C) second relapse. The tumor consists of cells characterized by a clear rim of cytoplasm and TFH phenotype as defined by the expression of PD1, CXCL13, BCL6, CD10, and ICOS (not shown); in panel A, it has a “follicular” growth pattern (hematoxylin and eosin, ×20), and in panel B, it has the typical “angioimmunoblastic” appearance (please note the hyperplastic HEV and the inflammatory component [hematoxylin and eosin, ×400]). In panel C, the “angioimmunoblastic” characteristics are lost and neoplastic cells acquire at least in part a more blastic appearance (hematoxylin and eosin, ×400).
