The current model for the recognition of platelet antigens by quinine-dependent antibodies. Current sandwich model (top). Summary of the findings of Zhu et al¹  in which quinine is mostly embedded in the quinine-dependent antibody and quinine binding alters the conformation of the paratope (middle). Possibility that under certain circumstances quinine may also alter the conformation of the epitope in a platelet antigen (bottom). The figure has been adapted from Figure 5 in the article by Zhu et al¹  that begins on page 2138. Professional illustration by Patrick Lane, ScEYEnce Studios.