Estimates of PFS, hazard of progression, OS, and prevalence of second tumors according to the model based on 17p deletion, 11q deletion, and IGHV mutation status. High-risk cases harboring 17p deletion independent of co-occurring 11q deletion or unmutated IGHV genes are color-coded in red. Intermediate-risk cases harboring unmutated IGHV genes and/or 11q deletion in the absence of 17p deletion are color-coded in yellow. Low-risk cases harboring mutated IGHV genes in the absence of 11q and 17p deletion are color-coded in blue. (A) PFS. (B) Estimate of the hazard of progression in relation to the time elapsed from FCR treatment start. (C) OS. The black line represents the expected OS in the age, sex, and calendar year of treatment-matched general population. P values according to Log-rank statistics. (D) Prevalence of second tumors among assessable cases of the three risk subgroups. Whiskers represent the 95% confidence interval (CI) of the proportion. P value according to Fisher’s exact test. na, not applicable; nr, not reached.