Simplified model of lectin-mediated BCR signaling in follicular lymphoma. N-linked oligomannose glycans within the variable region of sIg prevent binding of cognate antigen (●) but interact directly with mannose-binding lectins (DC-SIGN) expressed by dendritic cells and macrophages within the lymphoid microenvironment. Amin et al and Linley et al demonstrate that these interactions result in organization of the BCR (sIg, CD79a, and Cd79b) and CD19 coreceptor into signaling platforms with subsequent downstream phosphorylation of SYK, PLCγ2, ERK, and AKT (yellow). These signaling pathways can be blocked with inhibitors of SYK and BTK. Red P denotes phosphorylation events. Solid arrows indicate direct interactions and dotted arrows indicate that there are additional intermediates not shown.