Urine concentrating ability in chimeric SCD mice following IUHCT ± postnatal BMT. Urine osmolality was determined after 24 hours of water deprivation in naïve SCD mice (n = 5), naïve B6 mice (n = 4), chimeric SCD mice following IUHCT (n = 4), and chimeric SCD mice who underwent a postnatal boost following IUHCT (n = 4). *P < .05 vs naïve SCD mice.