Donor-cell engraftment, Hb levels, and DST following IUHCT. (A) PB of SCD, Thal, and B6 WT recipients of an IUHCT was analyzed for % total donor MNC engraftment and (B) % donor Hb. (A) *P < .05 for SCD vs WT; (B) Hb levels were statistically different with P < .05 between SCD vs WT and Thal vs WT with the exception of those marked by #; error bars: SEM. (C) At 6 months of life, PB was assessed for donor lymphomyeloid engraftment. (D) DST of chimeric mice following IUHCT was assessed by in vitro MLR. Responder splenocytes from chimeric SCD, chimeric Thal, and naïve B6 mice were assessed for proliferation against B6 (self), SJL/J (donor), and CBA (third-party) stimulators.