Representation of established myeloma-associated antigens in the HLA ligandomes of MM and HV. (A) Representation of previously described MM-associated antigens in HLA class I ligandomes. Bars indicate relative representation (%) of respective antigens by HLA class I ligands on primary MM samples, MCLs, and HV samples. Dashed lines divide the antigens into 4 groups according to their degree of MM association (MM and MCL-exclusive, MCL-exclusive, mixed presentation, HV-exclusive). (B-C) Distribution of myeloma-exclusive antigen presentation for (B) previously described antigens and (C) ligandome-defined TAAs on MCLs (white) and MM plus MCLs (shaded).