Figure 6
![Figure 6. PPXbd reduces thrombus resistance to fibrinolysis induced by recombinant tPA. (A-B) Recombinant tPA (30 nM) was added to PPXbd-treated whole blood (250 μg/mL) right before flow initiation (100 s−1; constant ΔP). Platelet deposition was identical with or without PPXbd during the first 400 seconds. However, the platelet signal reached a higher plateau level after occlusion (black arrows) when treated with PPXbd. Fibrinolysis was initiated after occlusion and proceeded faster in the presence of PPXbd at both (C) high and (D) low [TF]wall. Dynamics of platelet and fibrin accumulation were based on 3 clotting events (± SD, shaded area).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f6.jpeg?Expires=1723722427&Signature=EHThFF~rzoM5uBe9H4surztHxH7tQ6iqLexRREBB-2L8XnbAX~tLD63NTI-yFYKaFHWH6QP-RFADzklrUXFAK-Rae35hIRQDY4Alyh9D0CdPibq-dWvxAk41IcGRIwxKadWllUt9dV27xSLu4KbCryMvnKwtfZlAjRd2dDGhAcFE~RYiQ6SN9j0XE4T2L35WgDJd3-bn9bd1I-62LzFu4FRq7ndr~bsYG~~lDmBUwzGQcxe6imyngDlDhzdAEp1POuO6tDljuMLTnhpj~k6~COFbI4MAO34dxOq7EDz2cNq1jpjcvJNjOIiBAh3KQzxGspJBnk4h5cojNvUq3HfEEA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PPXbd reduces thrombus resistance to fibrinolysis induced by recombinant tPA. (A-B) Recombinant tPA (30 nM) was added to PPXbd-treated whole blood (250 μg/mL) right before flow initiation (100 s−1; constant ΔP). Platelet deposition was identical with or without PPXbd during the first 400 seconds. However, the platelet signal reached a higher plateau level after occlusion (black arrows) when treated with PPXbd. Fibrinolysis was initiated after occlusion and proceeded faster in the presence of PPXbd at both (C) high and (D) low [TF]wall. Dynamics of platelet and fibrin accumulation were based on 3 clotting events (± SD, shaded area).
