Figure 5
![Figure 5. PPXbd inhibits pathways downstream of FXIIa. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with (A) 14E11 (20 μg/mL) to inhibit FXIIa activation of FXI or (B) O1A6 to block FIX activation by FXIa and was perfused over collagen/low to medium [TF]wall surface at 100 s−1 under constant flow rate mode (constant Q). Adding PPXbd to 14E11-treated blood caused significant reduction in fibrin signal after the first 200 seconds. PPXbd showed no effect on fibrin generation when it was added to O1A6-treated blood.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f5.jpeg?Expires=1722700450&Signature=Pda9tGgQV1nx-Bu9RsQqvirGyXxCV8~ThKhORSATeNY2JeICvUrH5k3Wvwe3qBVsLkaIDZvu8MjD06mMbGgKgsZlr9y87v5K4bK6E8VY7Dgzs5zhoHnjhtfo8UtaXSUrGJex7EyhNmSy93FZawYtI4fN80YRZ-r0MX5e8xgTilhNI6-HnXf4M~iFN9PM8OeBhDih2rlm36q5km1IBXw-D-OL3y7nQH4IhPB0qai4M-cQgvJcOZZQMAg2xsHZrUQThGqVrPUyE3v7Z0iLqKugDawG8W~Klt3pb6lqMqdewzQMHa9ZJ~XFa-W2ilRb5-nBfHzYwXftkjNCP7DOP4MmUA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PPXbd inhibits pathways downstream of FXIIa. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with (A) 14E11 (20 μg/mL) to inhibit FXIIa activation of FXI or (B) O1A6 to block FIX activation by FXIa and was perfused over collagen/low to medium [TF]wall surface at 100 s−1 under constant flow rate mode (constant Q). Adding PPXbd to 14E11-treated blood caused significant reduction in fibrin signal after the first 200 seconds. PPXbd showed no effect on fibrin generation when it was added to O1A6-treated blood.
