Figure 2
![Figure 2. Potency of 14E11 and O1A6 varies depending on [TF]wall. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with FXI antibody 14E11 or O1A6 (20 μg/mL) and was perfused over collagen/TF surfaces at 100 s−1 (constant Q). (A-C) Platelet deposition on collagen was unaffected by FXI antibodies despite the difference in [TF]wall. (D-E) O1A6 showed inhibitory effect on fibrin generation at low and medium [TF]wall. (D) 14E11 only reduced fibrin generation at low [TF]wall. (F) Neither of the antibodies caused reduction in fibrin at high [TF]wall. *P < .05; **P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f2.jpeg?Expires=1722699252&Signature=lLKM78Rf-m1w7e2JdQN-kdyAzaqD6jX5oC3wPESamCVRpeSF5N0wGhg~qgdMuvw1dyVZW2Y6yARsnxi5X78qMpjp8yKeZmcK6uMi6l~xkKw5jOjcHlKiZKH~tPmgfgMY~cFZ-i~yBW31HUqVd-GU6oreNAc-kcdjcrt82WNvSE4O3rtGuWqC6q7ruMqjBbaMTiI1P2VpyR~ODCyDoSXqZky-sLJkl9338XVorKO~qIjlz6IqLqkumGxmSdgUWsojIbAwChcvKuQEued1PaC8lR1z~YgeObg1GfX5-llSKS~tp9ZzpJMr9pJk6kWy15QuvHSBx1PQgV9kWJPfLPAYCA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Potency of 14E11 and O1A6 varies depending on [TF]wall. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with FXI antibody 14E11 or O1A6 (20 μg/mL) and was perfused over collagen/TF surfaces at 100 s−1 (constant Q). (A-C) Platelet deposition on collagen was unaffected by FXI antibodies despite the difference in [TF]wall. (D-E) O1A6 showed inhibitory effect on fibrin generation at low and medium [TF]wall. (D) 14E11 only reduced fibrin generation at low [TF]wall. (F) Neither of the antibodies caused reduction in fibrin at high [TF]wall. *P < .05; **P < .01.
