Topical resiquimod therapy can induce the regression of both treated and untreated skin lesions. (A) Representative clinical images are shown of treated CTCL skin lesions before and after treatment in 3 patients. Lesions are shown before therapy (top) and at the indicated times after institution of therapy. (B) Representative clinical images of an untreated CTCL lesion before therapy (top) and at 16 weeks after beginning therapy to other sites (bottom).