Kinetics of hematopoiesis in leukemic BM. (A) Retroviral transduction procedure and induction of leukemia in nonirradiated recipient mice. (B) Absolute numbers of LT-HSCs, ST-HSCs, and multipotent progenitors in leukemic BM. (C-D) Absolute numbers of GMPs, CMPs, MEPs (D), and CLPs (E) in leukemic BM. Data are represented as the mean ± standard error of the mean (SEM) (n = 12; 3 independent experiments). (E) Reduced speed (upper panel) and a model (lower panel) showing the differentiation block from HSCs to HPCs. The numbers (eg, −5 and −29) indicate the fold decrease. Plus (+) or minus (−), increase or decrease. *P < .05; **P < .01; ***P < .001.