Tail bleeding time and accumulative hemoglobin loss after IV diabody, tPA, or diabody plus tPA. (A) Time until initial cessation of tail bleeding. (B) Accumulative bleeding up to 60 minutes, measured as g/dL hemoglobin. Data are expressed as the median of 9 to16 mice per group. *P < .05; **P < .01; ***P < .005.