Figure 1
Runx2 expression in MM cells does not affect cell proliferation but promotes tumor cell invasion in vitro. (A) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/in and control 5TGM1 cells. (B) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/d (Runx2 shRNA #90 and #91 transfectants) and NT control 5TGM1cells. No differences in cell proliferation were observed. Each sample was analyzed in triplicate and each assay was performed at least twice. (C) Invasion assay using Runx2 k/in and control 5TGM1 cells. (D) Invasion assay using Runx2 k/d (#90) and NT control 5TGM1 cells. Each sample was analyzed in triplicate and each assay was performed 3 times. Error bars represent mean ± SEM of each group. Significant differences between groups are indicated by P value.

Runx2 expression in MM cells does not affect cell proliferation but promotes tumor cell invasion in vitro. (A) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/in and control 5TGM1 cells. (B) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/d (Runx2 shRNA #90 and #91 transfectants) and NT control 5TGM1cells. No differences in cell proliferation were observed. Each sample was analyzed in triplicate and each assay was performed at least twice. (C) Invasion assay using Runx2 k/in and control 5TGM1 cells. (D) Invasion assay using Runx2 k/d (#90) and NT control 5TGM1 cells. Each sample was analyzed in triplicate and each assay was performed 3 times. Error bars represent mean ± SEM of each group. Significant differences between groups are indicated by P value.

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