Figure 1
Figure 1. Runx2 expression in MM cells does not affect cell proliferation but promotes tumor cell invasion in vitro. (A) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/in and control 5TGM1 cells. (B) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/d (Runx2 shRNA #90 and #91 transfectants) and NT control 5TGM1cells. No differences in cell proliferation were observed. Each sample was analyzed in triplicate and each assay was performed at least twice. (C) Invasion assay using Runx2 k/in and control 5TGM1 cells. (D) Invasion assay using Runx2 k/d (#90) and NT control 5TGM1 cells. Each sample was analyzed in triplicate and each assay was performed 3 times. Error bars represent mean ± SEM of each group. Significant differences between groups are indicated by P value.

Runx2 expression in MM cells does not affect cell proliferation but promotes tumor cell invasion in vitro. (A) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/in and control 5TGM1 cells. (B) MTT assay (top) and cell cycle flow cytometry (bottom) of Runx2 k/d (Runx2 shRNA #90 and #91 transfectants) and NT control 5TGM1cells. No differences in cell proliferation were observed. Each sample was analyzed in triplicate and each assay was performed at least twice. (C) Invasion assay using Runx2 k/in and control 5TGM1 cells. (D) Invasion assay using Runx2 k/d (#90) and NT control 5TGM1 cells. Each sample was analyzed in triplicate and each assay was performed 3 times. Error bars represent mean ± SEM of each group. Significant differences between groups are indicated by P value.

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