¹⁸FDG-PET in HIV-cHL. (A) Baseline ¹⁸FDG-PET. Volumetric image shows bulky intensely hypermetabolic cervical, mediastinal, and axillary lymph nodes and multiple focal bone lesions (representative vertebral lesion, red arrow). (B) Interim ¹⁸FDG-PET. At the end of cycle 2, coronal image focuses on a small suspicious lesion in left axilla (red arrow); diffuse bone uptake attributable to pegfilgrastim is also noted. After cycle 6, a biopsy sample of residual abnormalities in the left axilla showed reactive changes and no evidence of cHL. (C) End-of-therapy ¹⁸FDG-PET. Volumetric image shows resolution of ¹⁸FDG avid nodes. (D) Relapse ¹⁸FDG-PET. Volumetric image shows left axillary avid lymph node (red arrow) and other small nodes above the diaphragm.