Comparison between monocyte subset profile and monocyte count diagnosis. (A) ROC curves of the “MO1 percentage >94.0%” and “monocyte count >1 × 109/L” criteria to identify CMML at initial workup in the validation cohort. The difference between the 2 curves was highly significant (P < .0001, χ2 test). (B) Monocyte subset repartition analyzed in 2 independent samples obtained from 3 patients classified as having MDS and showing a fluctuating monocyte count of ∼1 × 109/L that precludes their classification as CMML according to the WHO criteria. (C) Monocyte subset repartition analyzed in 2 independent samples obtained from a patient who could be classified as having CMML according to the WHO criteria but who, based on cytologic and molecular analyses, demonstrates sideroblastic anemia with monocytosis.
