Monocyte subset profile as a biomarker of disease evolution. (A) Repeated evaluation of MO1 fraction in 21 untreated CMML patients followed from 6 to 26 months. (B) Evaluation of MO1 fraction in 7 CMML patients before and after treatment with azacytidine (AZA); all 7 patients responded to treatment.¹¹  (C-E) Evolution of monocyte subset repartition and monocyte count in CMML patients during treatment with a demethylating agent. (C) Patient who responded to azacytidine. (D) Patient who only transiently responded to azacytidine. (E) Patient who relapsed after initial response.