Increased HSPCs in Dnm2^fl/flPf4-Cre mice. Frequency of long-term (LT)-HSC, short-term (ST)-HSC, and multipotent progenitors (MPP) cells (A); LSK, lineage^lowKit^high (LK), common myeloid progenitor (CMP), granulocyte/macrophage progenitor (GMP), and megakaryocyte/erythroid progenitor (MEP) cells (B); and Pre-MegE, MK precursor (MKP), and Pre-CFU-E cells (C) in Dnm2^fl/fl and Dnm2^fl/flPf4-Cre bone marrows. Frequency of LT-HSC, ST-HSC, and MPP cells (D); LSK, LK, CMP, GMP, and MEP cells (E); and Pre-MegE, MKP, and Pre-CFU-E cells (F) in Dnm2^fl/fl and Dnm2^fl/flPf4-Cre spleens. Data represent mean ± SEM (n = 4 in each group; *P < .05; **P < .01; ***P < .0001).