Antiviral immune reconstitution after iC9–T-cell infusion. Quantification of pathogen-specific T cells detected by IFN-γ ELISPOT at multiple time points for each patient who did not receive AP1903. Pts. 5 (A) and 7 (B) had EBV reactivations, Pt. 12 had CMV reactivation (C), and Pt. 11 had HHV6 reactivation (D) before iC9–T-cell infusion. Pt. 7 had HHV6 infection (E), and Pt. 11 had VZV infection (F) after iC9–T-cell infusion. Black histograms represent response from total T cells and striped histograms represent response from endogenous T cells. The value of their difference represents the response from infused iC9-T cells. The gray dashed line indicates the viral load at multiple time points.