Association of GATA3 SNP rs3824662 with ALL in AYAs by race/ethnicity. In the discovery group (A) the A allele at rs3824662 was overrepresented in AYA ALL cases relative to non-ALL controls. This association was true within the European Americans (>95% European genetic ancestry), African Americans (>70% African ancestry), or Hispanic Americans (>10% Native American genetic ancestry, and Native American ancestry > African genetic ancestry). (B) Similar association was confirmed in the replication group (1-tailed test). Genetic ancestry was determined by using STRUCTURE (version 2.2.3) with HapMap CEU, YRI, CHB/JPT, and indigenous Native Americans as reference populations.