GWAS study design. ALL susceptibility variants were identified by comparing SNP genotype frequency in AYA ALL cases compared with non-ALL controls in the discovery GWAS, followed by replication. CALGB: The Alliance-Cancer and Leukemia Group B; COG: Children’s Oncology Group; ECOG: Eastern Cooperative Oncology Group; MDACC: MD Anderson Cancer Center; SJ: St. Jude Children’s Research Hospital.