Diagnostic flow-chart for laboratory classification of type 2 VWD. Diagnosis should be considered in patients with a significant bleeding history and plasma VWF:RCo below 40 IU/dL. Asterisk denotes that VWF:Ag or VWF:CBA should be reduced proportionally to VWF:RCo. In addition to this flow-chart, type 2N should be considered in patients with a significant bleeding history and a FVIII/VWF:Ag ratio below 0.6; VWF:FVIIIB is used to differentiate from mild hemophilia A.