Structural alterations in patients with hematologic conditions. In both patient groups, cortical bone erosion was present, causing a significant increase in the ratio between intraosseous space and total SV (A). This difference was largely caused by marked erosion in the appendicular district (C), whereas the axial skeleton was unmodified (B). (D-G) Transaxial slices of a transplanted patient (E, G), showing visible cortical erosion, as compared with a matched control (D, F). (H-I) Mean intensity projections of a coronal slice of femurs, showing marked erosion in the transplanted patient (I), compared with control (H). Significance was represented as follows: *P < .05; **P < .01.