Figure 1
![Figure 1. Loss of Trp53 but not of Cdkn2a, restores HSPC content in Ercc1-/*292 mice. (A, E) LSK frequencies in lin− fractions of indicated mouse genotypes at 3 weeks of age are shown. (B-D and F-H) CFUs per 5 × 104 unfractionated BM cells in the presence of indicated growth factors relative to the WT controls are shown. All bars represent the mean and standard deviations (SD) of n ≥3 mice. The significance was calculated by the Student t tests (asymptotic significance [2-tailed]), *P < .05].](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/125/25/10.1182_blood-2014-11-612507/4/3937f1.jpeg?Expires=1722759317&Signature=Ba4FuTkNJIysX2sL77AFLRe9eyQjc0C1Bc--a0WxgeIjryaJ41XBrh7Bu1uUsu0t6EBDmz14Eh-b7dVpDDebjldtONrh0sb8gKg2rF0C452cI4LXKP8T2naCPbftCgQiG-mfm1AfbILcghDxFBxwRhTNBrA83nUHOBfXPd22ddgShdDGsLbap6JIohYXvlKtvgJSQkJtOhD~vjXsPPyhZMerSo7nxufU7Pa6~~i7HAq6KsXOpOxNkGhb5cGG6ABH7cGv5obw~ZdB9UsBiUhkt3ANrYNbc22akSCiWVXWeKIIwQ4vh1VC8AIW2ED7Tbe8XCtJ3S4jpGkkGeUwTLVh9g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Loss of Trp53 but not of Cdkn2a, restores HSPC content in Ercc1-/*292 mice. (A, E) LSK frequencies in lin− fractions of indicated mouse genotypes at 3 weeks of age are shown. (B-D and F-H) CFUs per 5 × 104 unfractionated BM cells in the presence of indicated growth factors relative to the WT controls are shown. All bars represent the mean and standard deviations (SD) of n ≥3 mice. The significance was calculated by the Student t tests (asymptotic significance [2-tailed]), *P < .05].
