ABL1-class rearrangements in Ph-like ALL. The figure shows each ALL sample as a column, each kinase rearrangement as a green box, and the diverse range of fusion partners in blue. On the right, representative schema of fusion proteins are shown, showing preservation of the kinase domain in the C terminus of the protein and fusion partners uniformly in the 5′ region of the protein, with domains that mediate overexpression of the kinase, cellular mislocalization, and dimerization of the fusion protein. TKD, tyrosine kinase domain.