Identification of novel mutations in STAT6 in FL. (A) Schema of the STAT6 protein domain structure. The approximate location of somatic mutations identified in STAT6 in FL is indicated. Sanger sequence chromatograms showing results for FL B-cell– and paired CD3⁺ T-cell–derived DNA. (B-C) Homology model of the STAT6-DNA complex. (B) STAT6 dimer with individual monomers in green and cyan. (C) STAT6 residues undergoing mutation are close to the DNA binding interface and are displayed in ball-and-stick diagrams. The graphic was generated with the PyMOL program.