Expression of cereblon, ikaros, and aiolos protein in tumor cells and its correlation with clinical response. Expression of these proteins in bone marrow biopsies at baseline at study entry was quantified by immunohistochemistry as an H-score. (A) Correlation between immunohistochemical H-scores for ikaros, cereblon, and aiolos protein expression in tumor cells. (B) Expression of ikaros, cereblon, and aiolos protein vs objective clinical response (≥PR).