Normal plasma VWF subjected to sizing chromatography was analyzed by sodium dodecyl sulfate agarose gel electrophoresis (C). Fractions with smaller multimers (dimers, tetramers, hexamers) enhanced CFI-mediated degradation of C3b, generating inactivated C3b (iC3b) with 68-kDa and 43-kDa bands resulting from proteolysis of the 110-kDa α′ chain of C3b (D). Fractions with larger VWF multimers did not promote C3b degradation. See Figure 2 in the article by Feng et al that begins on page 1034.