MEDI2452 reversal of ADP-induced whole blood aggregation ex vivo. (A) Individual data for each treatment group after the stop of ticagrelor infusion. Vehicle control (▪), ticagrelor alone (●), ticagrelor plus MEDI2452 (○), and ticagrelor plus isotype control (Δ). Open bar represents mean data (n = 4). AU*min, area under aggregation curve per minute. At 15 minutes, data were collected only for the ticagrelor-plus-MEDI2452 group. (B) Percentage reversal induced by MEDI2452; mean data (n = 4) ± SEM.