MEDI2452 reversal of ADP-induced human platelet aggregation in vitro. (A) MEDI2452 concentration-dependent reversal of 1 μM ticagrelor (○) or 1 μM TAM (●) mediated inhibition of 20 μM ADP-induced aggregation. (B) Reduction of free-ticagrelor concentration in plasma in the presence of 1 μM ticagrelor. Mean (n = 5) ± SEM.