Specificity of Fabs assessed by competitive inhibition of Fab binding to biotinylated ticagrelor. (A) Structures of ticagrelor, TAM, TIM, and biotinylated ticagrelor. The substituent R groups of ticagrelor are indicated. (B) Specificity profile of Fab 72. (C) Specificity profile of MEDI2452. Data shown are for ticagrelor, TAM, TIM, adenosine, ADP, ATP, and 3 of the 12 structurally related compounds tested for clarity. No binding was detected to any of the 12 structurally related compounds at concentrations up to 0.1 mM. Data are mean ± standard error of the mean (SEM) for 3 replicates.