Proposed tumor suppressor role of SOX7 in AML. (A) SOX7 expression is normally silenced in AML by promoter CpG island hypermethylation. Wnt/β-catenin signaling is unopposed. SOX7 silencing might be associated with downregulation of other tumor suppressors (?TS). Both SOX7 suppression and Wnt/β-catenin activity might result in leukemogenesis. (B) When SOX7 was expressed, β-catenin was bound and Wnt/β-catenin signaling was checked. SOX7 might induce expression of other tumor suppressors, including SOX6 and Sprouty 3 (SPRY3). These changes were associated with an antileukemia effect on AML.