Effect of tumor-derived IDO on CD19-CARTs. (A) Schematic representation of the experiments in SCID/Beige mice comparing the antitumor effects of CD19-CARTs on Raji-control (left flank) and Raji-IDO tumor (right flank). (B) Time course of tumor bioluminescence in mice treated with nontransduced (NT) T cells or CD19-CARTs. (C) Time course of bioluminescence of Raji-control and Raji-IDO tumors treated with NT and CARTs. Data represent mean ± SD of 8 mice per group from 2 independent experiments (*P < .05).