Eosinophils. (A) Schematic representation of consequences of eosinophil life or death in homeostasis and disease. (B) Schematic signal transduction pathway leading to IL-5–mediated eosinophil survival. Bcl-xL, B-cell lymphoma–extra large; βc, common β chain; GI, gastrointestinal; IκB, inhibitor of NF-κB; IL-5Rα, IL-5 receptor α; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; STAT5, signal transducer and activator of transcription 5.

Eosinophils. (A) Schematic representation of consequences of eosinophil life or death in homeostasis and disease. (B) Schematic signal transduction pathway leading to IL-5–mediated eosinophil survival. Bcl-xL, B-cell lymphoma–extra large; βc, common β chain; GI, gastrointestinal; IκB, inhibitor of NF-κB; IL-5Rα, IL-5 receptor α; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; STAT5, signal transducer and activator of transcription 5.

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