Model of miR-24-mediated regulation of VWF biosynthesis and secretion through the aldose reductase pathway. Hyperglycemia upregulates aldose reductase activity and increases ROS generation in endothelial cells. Increased ROS upregulates c-Myc/c-Myc phosphorylation, which downregulates miR-24, leading to increased expression of VWF, Furin, and HRH1. Therefore, the expression of VWF itself, Furin-dependent VWF maturation, and the histamine-regulated secretion pathways are coordinately upregulated with hyperglycemia.