Severity of cGVHD and ROC curve analysis. (A) Association between the severity of cGVHD at diagnosis and HY score at 3 months post-HCT. (B) Predictive potential for cGVHD by ROC curve analysis, comparing HY score alone, clinical factors (CF) alone, and their combination. The AUCs of HY score and clinical factors alone were 0.67 and 0.69, respectively; but when combined, the AUC increased to 0.81 (P < .01 in each comparison with the combination). Clinical factors included age of patient and donor, diagnosis of chronic myeloid leukemia, disease risk, CMV serostatus, donor types, cell sources, usage of total body irradiation, usage of anti-thymocyte globulin, and grade of aGVHD.^5,6  NIH, National Institutes of Health.