ADAMTS13 domain structure and functional genetic variants. Variants boxed with green are located within the ADAMTS13 locus. Variants boxed with red are significantly associated common variants among genome-wide SNPs. Variants boxed with blue are significantly associated rare variants among exome-wide SNPs. Act., percentage of increased or decreased plasma ADAMTS13 activity; C, Cys-rich domain; CUB, complement C1r/C1s; D, disintegrin-like domain; Freq., allele frequency; M, metalloprotease domain; P, propeptide; S, signal peptide sequence; Sp, spacer domain; T, thrombospondin type 1 repeat.